Morphofunctional Characteristics of Pulmonary Surfactant System and Its Effect on Immune Cells in Influenza A(H1N1) Pathogenesis
نویسندگان
چکیده
There is an annual increase of influenza-related SARI cases in winter months. Despite the high relevance of this problem, influenza pathogenesis and the role of surfactant system and its SP-A (surfactant protein A) enzyme in antiviral defense remain poorly understood. SP-A activates macrophage M1 polarization and triggers an antiviral response due to the activation of T-cells and dendritic cells. Therefore, surfactant system is an important element of infection protection and a promising therapeutic target.
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